Presynapses go nuclear!
نویسندگان
چکیده
Decades of research has shown that long-term changes in synaptic function ultimately require changes in gene expression.Recent work has focused on nuclear signaling by calcium and protein messengers initiated at postsynaptic sites. In this issue of The EMBO Journal, Ivanova and colleagues show that shuttling of CtBP-1 between presynaptic areas and nuclei regulates gene expression, which reminds us that presynaptic zones should not be ignored when considering synapse-to nucleus signaling.
منابع مشابه
Presynapses in Kenyon cell dendrites in the mushroom body calyx of Drosophila.
Plastic changes at the presynaptic sites of the mushroom body (MB) principal neurons called Kenyon cells (KCs) are considered to represent a neuronal substrate underlying olfactory learning and memory. It is generally believed that presynaptic and postsynaptic sites of KCs are spatially segregated. In the MB calyx, KCs receive olfactory input from projection neurons (PNs) on their dendrites. Th...
متن کاملSynaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Persistent experience-driven adaptation of brain function is associated with alterations in gene expression patterns, resulting in structural and functional neuronal remodeling. How synaptic activity-in particular presynaptic performance-is coupled to gene expression in nucleus remains incompletely understood. Here, we report on a role of CtBP1, a transcriptional co-repressor enriched in presyn...
متن کاملSynphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease.
α-Synuclein is a major component of Lewy bodies in Parkinson disease (PD) and dementia with Lewy bodies (DLB). We recently showed that abnormal α-synuclein with resistance to proteinase K (PK) is deposited at presynapses of distinct brain anatomic regions from the early stages of PD and DLB. NUB1, a synphilin-1-binding protein, also accumulates in Lewy bodies, but it is not known whether abnorm...
متن کاملSynthesis of graphene oxide-TiO2 nanocomposite as an adsorbent for the enrichment and determination of rutin
Objective(s): In our study, graphene oxide-TiO2 nanocomposite (GO/TiO2) was prepared and used for the enrichment of rutin from real samples for the first time. Materials and Methods: The synthesized GO/TiO2 was characterized by X-ray diffraction, scanning electron microscopy, and FT-IR spectra. The enrichment process is fast and highly efficient. The factors including contact time, pH, and...
متن کاملLinearity response characterization of Polystyrene/ Graphene oxide nanocomposite as real-time dosimeter for therapeutic purposes
Introduction: In recent years, one of the emerging two dimensional (2D) carbon based nano- materials namely Graphene Oxide has been incorporated into polymeric matrices to enhance the electrical properties of the composites. The electrical conductivity of Graphene Oxide is excellently used in fabricating polymer-based sensors, energy-related systems, biotechnology, anti-statics...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The EMBO journal
دوره 34 8 شماره
صفحات -
تاریخ انتشار 2015